Notice for International Patients & Caregivers

English summary does not mean the trial enrolls international patients. Multiple myeloma interventional clinical trials in China typically require valid Chinese resident identity/national healthcare insurance and strict adherence to China's Human Genetic Resources Administration regulations.

Clinical Line Focus
Snapshot: 2026-10-21

Newly Diagnosed Multiple Myeloma (NDMM) Trials Landscape

Newly diagnosed multiple myeloma (NDMM) represents the most critical therapeutic window for achieving initial deep MRD negativity. Active trials in China focus on quadruplet induction regimens and early frontline cell therapy integrations.

As of 2026-10-21, there are 4 active interventional trials dedicated to this patient population in China.

Active Trials
4
Provinces
26
Centers
110

Clinical Characteristics & Guidance

For transplant-eligible patients, frontline clinical trials aim for deep MRD negativity; for transplant-ineligible elderly patients, the focus is optimal efficacy with balanced tolerability.

Enrollment must typically be evaluated before starting systematic first-line chemotherapy to prevent prior exposure exclusions.

Participants receive specialized monitoring at top-tier hematology centers with investigational drugs and study-related tests covered by sponsors.

Active Studies (4)

Population synthesized by CMDN

Showing 4 published English records of 4 registry trials.

Phase IIICTR20233883
Recruiting

An Open-Label, Two-Arm, Multicenter, Randomized, Phase III Study Evaluating the Efficacy and Safety of ELRANATAMAB (PF-06863135) + Daratumumab + Lenalidomide Versus Daratumumab + Lenalidomide + Dexamethasone in Study Participants with Newly Diagnosed Multiple Myeloma (NDMM) Who Are Transplant-Ineligible or Deferred Transplant

Population: Newly diagnosed/Relapsed/refractory
Target: BCMA × CD3 bispecific antibody
Study Sites: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences、Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology、The First Affiliated Hospital, Zhejiang University School of Medicine、Sun Yat-sen University Cancer Center 等 17 家中心
Phase IIICTR20241434
Recruiting

A Phase III, Randomized Study Comparing Teclistamab in Combination With Subcutaneous (SC) Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With SC Daratumumab and Lenalidomide (Tal-DR) Versus SC Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Not Eligible or Not Planned for Autologous Stem Cell Transplantation as Initial Therapy

Population: Newly diagnosed
Target: BCMA × CD3 bispecific antibody (MajestTEC-7 study)
Study Sites: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences、Renji Hospital, Shanghai Jiao Tong University School of Medicine、Henan Cancer Hospital、Sun Yat-sen University Cancer Center 等 32 家中心
Phase IIICTR20232917
Recruiting

A Two-Stage, Randomized, Multicenter, Controlled, Open-Label, Phase III Study Comparing Iberdomide Maintenance Therapy with Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT) in Participants with Newly Diagnosed Multiple Myeloma (NDMM)

Population: Newly diagnosed/Maintenance
Target: Oral small-molecule "molecular glue" degrader (next-generation Cereblon E3 ligase modulator [CELMoD])
Study Sites: Peking University People's Hospital、Tongji Medical College of Huazhong University of Science and Technology、Qilu Hospital of Shandong University、Jiangsu Province Hospital 等 37 家中心
Phase ICTR20260785
Recruiting

A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetic Profile, Safety, Tolerability, and Immunogenicity of HLX15-SC Versus DARZALEX FASPRO; Combined with Lenalidomide-Dexamethasone (Rd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible for Transplantation

Population: Newly diagnosed
Target: Recombinant fully human anti-CD38 monoclonal antibody
Study Sites: Zhongshan Hospital, Fudan University、Peking University Third Hospital、Guangzhou First People's Hospital、The Third Hospital of Hebei Medical University 等 66 家中心