Notice for International Patients & Caregivers

English summary does not mean the trial enrolls international patients. Multiple myeloma interventional clinical trials in China typically require valid Chinese resident identity/national healthcare insurance and strict adherence to China's Human Genetic Resources Administration regulations.

Clinical Line Focus
Snapshot: 2026-09-04

Newly Diagnosed Multiple Myeloma (NDMM) Trials Landscape

Newly diagnosed multiple myeloma (NDMM) represents the most critical therapeutic window for achieving initial deep MRD negativity. Active trials in China focus on quadruplet induction regimens and early frontline cell therapy integrations.

As of 2026-09-04, there are 4 active interventional trials dedicated to this patient population in China.

Active Trials
4
Provinces
26
Centers
111

Clinical Characteristics & Guidance

For transplant-eligible patients, frontline clinical trials aim for deep MRD negativity; for transplant-ineligible elderly patients, the focus is optimal efficacy with balanced tolerability.

Enrollment must typically be evaluated before starting systematic first-line chemotherapy to prevent prior exposure exclusions.

Participants receive specialized monitoring at top-tier hematology centers with investigational drugs and study-related tests covered by sponsors.

Active Studies (4)

Population synthesized by CMDN

Showing 2 published English records of 4 registry trials.

Phase IIICTR20232917
Recruiting

A Two-Stage, Randomized, Multicenter, Controlled, Open-Label, Phase III Study Comparing Iberdomide Maintenance Therapy with Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT) in Participants with Newly Diagnosed Multiple Myeloma (NDMM)

Population: Newly diagnosed/Maintenance
Target: Oral small-molecule "molecular glue" degrader (next-generation Cereblon E3 ligase modulator [CELMoD])
Study Sites: Peking University People's Hospital、Tongji Medical College of Huazhong University of Science and Technology、Qilu Hospital of Shandong University、Jiangsu Province Hospital 等 37 家中心
Phase ICTR20260785
Recruiting

A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetic Characteristics, Safety, Tolerability, and Immunogenicity of HLX15-SC Versus DARZALEX FASPRO Combined with Lenalidomide-Dexamethasone (Rd) in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma

Population: Newly diagnosed
Target: Recombinant fully human monoclonal antibody targeting CD38
Study Sites: Zhongshan Hospital Affiliated to Fudan University、Peking University Third Hospital、Guangzhou First People's Hospital、The Third Hospital of Hebei Medical University 等 66 家中心