RecruitingEarly Exploratory Clinical StudyNCT07715630Relapsed/refractory multiple myeloma (RRMM)IIT Study

Relapsed/refractory multiple myeloma · relapsed/refractory multiple myeloma Early Exploratory Clinical Study

Official protocol title:In Vivo-Generated PICX Chimeric Antigen Receptor T-cell (CAR-T) Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM)

Sponsor: Chongqing Precision BiotechLead: The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation ArmyUpdated: 9/21/2026
Target CohortRelapsed/refractory(Synthesized by CMDN from protocol summary; final eligibility confirmed by study doctors)

Trial Summary

This study aims to evaluate the safety, tolerability, and preliminary efficacy of in vivo-generated PICX chimeric antigen receptor T-cell (CAR-T) therapy in patients with relapsed or refractory multiple myeloma. Eligible participants will receive a single intravenous infusion of PICX, followed by a one-month inpatient observational period post-infusion and up to 2 years of follow-up monitoring. This clinical trial is conducted at the 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army.

Participating Centers0 in China + 1 overseas

The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army

Source and Verification

Every fact on this page is derived from the official study protocol document below. The source document is archived as a PDF for direct verification.

Document type
Clinical trial registry record (archived PDF)
Official registration number
NCT07715630ClinicalTrials.gov ID
Verify on ClinicalTrials.govto view the detailed public study protocol and history (ID: NCT07715630).
Last reconciled
2026-09-21

Frequently Asked Questions about this Study

Structured facts derived from official protocol filings for patient and family reference

QWhich patient group is targeted by this clinical trial?

According to official protocol filings (target population synthesized by CMDN from study details, not an official registry field), this study is primarily designed for patients with [Relapsed/refractory]. Eligibility requires verified clinical confirmation by investigators regarding prior lines of therapy, active disease biomarkers, and performance status.

QWhat are the specific eligibility criteria regarding age, performance status, and prior therapy?

According to verified protocol filings, key eligibility thresholds include: age ≥ 18 years, ECOG performance status ≤ 2. The study specifies 7 inclusion and 7 exclusion criteria covering detailed organ function and medical history. Final enrollment confirmation is determined by investigators at participating hospital trial centers.

QWhat are the investigational targets and mechanism of action?

The core therapeutic target or investigational mechanism is [Relapsed/refractory multiple myeloma (RRMM)]. It aims to selectively eradicate clonal plasma cells or redirect anti-tumor immune responses, representing an active area of precision hematology research.

QWhat clinical phase is this study in?

This study is registered as a [Early Exploratory Clinical Study] clinical trial. The protocol is conducted under rigorous ethical and Good Clinical Practice (GCP) oversight approved by institutional ethics committees.

QWhere are the participating hospital trial centers located?

This is an international multi-centre study with 0 study centres in China and 1 overseas centres. The lead institution is [The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army]. Prominent sites include The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army. Eligible domestic patients can seek screening at the nearest participating centre.

QWhat is the official trial registration code and how can it be verified?

The official public registration identifier for this protocol is [NCT07715630] (CLINICALTRIALS_GOV). Patients and researchers can verify registration details and authorizations on ClinicalTrials.gov.

Note for International Patients: Trial centers for this study are located in China. Interventional trials strictly comply with domestic Human Genetic Resources (HGRAC) regulations and standard hospital protocols, which generally restrict enrollment to residents with domestic healthcare identification. International patients seeking approved cellular therapies should review commercial options.

Key Information

Status

Recruiting

Phase

Early Exploratory Clinical Study

Target / Therapy

Relapsed/refractory multiple myeloma (RRMM)

Sponsor

Chongqing Precision Biotech

Lead Institution

The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army

Participating Centers

0 in China + 1 overseas

ClinicalTrials.gov ID

NCT07715630

Trial information is synthesized from the official study protocol filings and reviewed by CMDN. Confirm current status and eligibility with the study team.

Where this study sits in the landscape

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Keywords

PICXCAR-Tmultiple myelomarelapsed/refractory

Considering a non-trial option?

International participation must be confirmed directly with the study team. If a clinical trial is not practical, review our independent guide to CAR-T in China.

View CAR-T in China Guide →

Evidence · Process · Costs · Verified hospitals

Patient Rights & Safety Assurance

Protocol drugs and related tests are fully covered by the sponsor. All studies are strictly supervised by ethics committees, and patients retain the legal right to withdraw at any time.

Read application guide & patient rights
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