BCMA/CD70 CAR-T · relapsed/refractory multiple myeloma Early exploratory clinical study
Official protocol title:In Vivo-Generated PICX Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM)
Trial Summary
This study aims to evaluate the safety, tolerability, and preliminary efficacy of in vivo-generated PICX chimeric antigen receptor T-cell (CAR-T) therapy in patients with relapsed or refractory multiple myeloma. Eligible participants will receive a single intravenous infusion of PICX, followed by a one-month inpatient observation period and up to 2 years of follow-up monitoring. This clinical trial is conducted at the 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army.
Participating Centers0 in China + 1 overseas
Source and Verification
Every fact on this page is derived from the original filing below. The source document is archived as a PDF for direct verification.
- Document type
- Clinical trial registry record (archived PDF)
- Official registration number
- No CDE registration number
- Last reconciled
- 2026-09-03
Frequently Asked Questions about this Study
Structured facts derived from official protocol filings for patient and family reference
According to official protocol filings (target population synthesized by CMDN from study details, not an official registry field), this study is primarily designed for patients with [Relapsed/refractory]. Eligibility requires verified clinical confirmation by investigators regarding prior lines of therapy, active disease biomarkers, and performance status.
According to verified protocol filings, key eligibility thresholds include: age ≥ 18 years, acceptable performance status. The study specifies 7 inclusion and 7 exclusion criteria covering detailed organ function and medical history. Final enrollment confirmation is determined by investigators at participating hospital trial centers.
The core therapeutic target or investigational mechanism is [BCMA/CD70 CAR-T]. It aims to selectively eradicate clonal plasma cells or redirect anti-tumor immune responses, representing an active area of precision hematology research.
This study is registered as a [Early exploratory clinical study] clinical trial. The protocol is conducted under rigorous ethical and Good Clinical Practice (GCP) oversight approved by institutional ethics committees.
This is an international multi-centre study with 0 study centres in China and 1 overseas centres. The lead institution is [The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army]. Prominent sites include The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army. Eligible domestic patients can seek screening at the nearest participating centre.
The official public registration identifier for this protocol is [NCT07715630] (CLINICALTRIALS_GOV). Patients and researchers can verify registration details and authorizations on ClinicalTrials.gov.
Key Information
Status
Recruiting
Phase
Early exploratory clinical study
Target / Therapy
BCMA/CD70 CAR-T
Sponsor
Chongqing Precision Biotech
Lead Institution
The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Participating Centers
0 in China + 1 overseas
ClinicalTrials.gov ID
NCT07715630Trial information is translated from the Chinese source record and reviewed by CMDN. Confirm current status and eligibility with the study team.
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Considering a non-trial option?
International participation must be confirmed directly with the study team. If a clinical trial is not practical, review our independent guide to CAR-T in China.
View CAR-T in China Guide →Evidence · Process · Costs · Verified hospitals
Protocol drugs and related tests are fully covered by the sponsor. All studies are strictly supervised by ethics committees, and patients retain the legal right to withdraw at any time.
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